Case series on anti-melanoma differentiation-associated gene 5+ dermatomyositis associated with interstitial lung disease

Dermatomyositis (DM) associated with anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is a rare autoimmune disease. Anti-MDA5, also known as anti-CADM-140 antibodies. DM affects the skeletal muscle, skin, joints, and lungs form of idiopathic inflammatory myopathy (IIM). All dermatomyositis MDA5+ positive patients had rapidly progressive interstitial lung disease (RP-ILD). classified into 2 types, classic (CDM) clinically amyopathic (CADM). Anti-MDA5 antibody-positive RP-ILD without signs or CADM. in CADM antibodies to MDA5 has high mortality rate. diagnosed by rashes (Gottron’s papules Gottron’s sign heliotrope rash) anti-MDA5. includes acute/subacute pneumonia, which deterioration ILD. Immunosuppressives are effective agents for treatment anti-MDA5-positive